How does selenium exert its antioxidant action at the molecular level?

Label:chem

Topic
A study states that oxidative stress is a key driver of metabolic dysfunction-associated steatotic liver disease (MASLD).
Answer
Selenium-dependent glutathione peroxidases (GPX1-4) use GSH to reduce H₂O₂ and organic hydroperoxides, while thioredoxin reductases (TXNRD1-3) maintain reduced thioredoxin, collectively quenching reactive oxygen species (ROS) produced during hepatic lipid accumulation.
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