What mechanisms explain curcumin’s neuroprotective effects?

Label:chem

Topic
Animal and cellular studies elucidate curcumin’s mechanisms against Alzheimer’s pathology.
Answer
Curcumin exhibits antioxidant, anti-inflammatory, and anti-amyloidogenic effects, inhibiting Aβ aggregation/tau hyperphosphorylation, promoting Aβ clearance by macrophages, enhancing autophagy (via Beclin-1/PI3K/Akt/mTOR), and restoring synaptic plasticity (LTP).
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