What are the roles of vitamin E isomers in neuroprotection?

Label:chem

Topic
Vitamin E is a group of fat-soluble compounds with potent antioxidant properties that contribute to various physiological functions, including immune regulation, cardiovascular protection, and cellular defense mechanisms. The antioxidant function of vitamin E involves scavenging reactive oxygen species (ROS) and reactive nitrogen species (RNS), thereby preventing lipid peroxidation in cell membranes, lipoproteins, and mitochondrial structures.

From: "Shifting Perspectives on the Role of Tocotrienol vs. Tocopherol in Brain Health: A Scoping Review", Int. J. Mol. Sci. 2025, 26(13), 6339;
Answer
Vitamin E isomers, including tocopherols and tocotrienols, play significant roles in neuroprotection. They scavenge free radicals, regulate inflammatory pathways, and maintain membrane stability. Tocopherols, particularly α-tocopherol, are associated with improved cognitive performance and reduced neuroinflammation. Tocotrienols, while less studied, show potential in reducing oxidative damage and protecting brain structure, particularly in white matter.
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