What is the role of the CB2 receptor in the antihyperalgesic effect of 4-methylaminoantipyrine (4-MAA)?

Label:chem

Topic
The study investigates the involvement of the CB2 receptor, a peripheral cannabinoid receptor, in the antihyperalgesic effect of 4-MAA, which is a bioactive metabolite of dipyrone.

From: "Dipyrone is locally hydrolyzed to 4-methylaminoantipyrine and its antihyperalgesic effect depends on CB2 and kappa-opioid receptors activation", European Journal of Pharmacology, Volume 874, 5 May 2020, 173005
Answer
The antihyperalgesic effect of 4-MAA is mediated by CB2 receptor activation, as shown by the reversal of this effect with a selective CB2 receptor antagonist (AM630). This suggests that the activation of CB2 receptors plays a crucial role in the analgesic mechanism of 4-MAA, likely through the release of endogenous opioids that subsequently activate kappa-opioid receptors.
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