What is the role of dipyrone in postoperative analgesia after tonsillectomy in children?

Label:chem

Topic
Dipyrone is one of the most widely used painkillers in the postoperative period in children. Its use, however, is controversial due to potential severe adverse effects such as agranulocytosis, leading to its ban in many countries. Despite this, dipyrone is still widely used in some regions, including Brazil, due to its low cost and availability in injectable form. The study aims to review the analgesic use of dipyrone in the postoperative period of tonsillectomy in children.

From: "Dipyrone as pre-emptive measure in postoperative analgesia after tonsillectomy in children: a systematic review", Brazilian Journal of Otorhinolaryngology, Volume 87, Issue 2, March–April 2021, Pages 227-236
Answer
Dipyrone has been shown to have an analgesic effect superior to placebo and similar to paracetamol in the postoperative period of tonsillectomy in children. It appears to be suitable for use in children. However, due to the scarcity of randomized clinical trials evaluating its analgesic effect in this age group, more well-designed studies are needed to establish its role in postoperative pain management. The risk of agranulocytosis, while real, is considered low, especially in Latin America, making dipyrone a potentially valuable option for postoperative pain relief in low-income countries where cost and availability are significant factors.
Return to Home Chemical List
Knowledge you may be interested in
Does dipyrone exhibit (anti)estrogenic activity in vivo or in vitro? What is the mechanism behind the gas sensing performance of the MoSe2/TiO2 composite? How does the MoSe2/TiO2 composite achieve high selectivity for NH3 and DMF? What is the response time and recovery time of the MoSe2/TiO2 composite sensor for NH3 and DMF? What are the detection limits for NH3 and DMF using the MoSe2/TiO2 composite sensor? How does the MoSe2/TiO2 composite enhance gas sensing performance? What is the role of MoSe2/TiO2 composite in gas sensing? What is the significance of using the Disability-Adjusted Life Year (DALY) and Willingness to Pay (WTP) models in the monetization of health risks associated with DMF exposure? How is the external exposure to dimethylformamide (DMF) reconstructed using the biomarker N-methylcarbamoyl hemoglobin (NMHb)? What are the health risks associated with long-term exposure to dimethylformamide (DMF) in occupational settings? What is the role of dipyrone and its metabolite 4-methylaminoantipyrine (4-MAA) in the local antihyperalgesic effect, and which receptors are involved in this effect? How is dipyrone metabolized in peripheral tissue, and what is the significance of this metabolism in its analgesic effect? Which opioid receptors are involved in the antihyperalgesic effect of 4-methylaminoantipyrine (4-MAA)? What is the role of the CB2 receptor in the antihyperalgesic effect of 4-methylaminoantipyrine (4-MAA)? What are the effects of tocotrienol and tocopherol supplementation on brain health? How do tocotrienol and tocopherol differ in their effects on brain health? What are the roles of vitamin E isomers in neuroprotection? How does vitamin E supplementation affect cognitive performance in humans? What are the effects of vitamin E on neuroinflammation and oxidative stress in the brain? What tocopherols and tocotrienols are found in Hypericum perforatum L. inflorescences?