What is the role of rokitamycin in inducing apoptosis in human T-cell leukemia Jurkat cells?

Label:chem

Topic
Rokitamycin (RKM) is a semisynthetic macrolide antibiotic with a 16-member ring structure. Macrolides are known for their bactericidal effects and have recently been shown to have immunomodulatory activities. This study investigates whether rokitamycin can induce apoptosis in human leukemia cell lines, specifically focusing on the Jurkat cell line.

From: "Rokitamycin Induces a Mitochondrial Defect and Caspase-Dependent Apoptosis in Human T-Cell Leukemia Jurkat Cells", Journal of Pharmacological Sciences, Volume 110, Issue 1, 2009, Pages 69-77
Answer
Rokitamycin effectively induces apoptosis in Jurkat cells by causing mitochondrial defects, reducing mitochondrial transmembrane potential (ΔΨm), and releasing cytochrome c from mitochondria to the cytosol. This process activates caspases, leading to cell death. The study concludes that rokitamycin has pro-apoptotic activity in human leukemia cells, independent of its bactericidal effects.
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