What is the role of GilR in the biosynthesis of gilvocarcin V?

Label:chem

Topic
GilR is an oxidoreductase enzyme that catalyzes the final step in the biosynthesis of gilvocarcin V, an anticancer compound. This enzyme is responsible for converting the hemiacetal intermediate, pregilvocarcin V, into the central lactone core of the polyketide-derived tetracyclic ring skeleton of gilvocarcin V.
Answer
GilR plays a crucial role in the biosynthesis of gilvocarcin V by catalyzing the conversion of pregilvocarcin V into gilvocarcin V through a unique lactone-forming reaction. This step is essential for the formation of the active anticancer compound.
Return to Home Chemical List
Knowledge you may be interested in
How does gamma radiation affect the corrosion behavior of copper in the presence of Ag/AgCl quasi-reference electrodes (QREs)? What is the significance of the AgCl coating on the stability of Ag/AgCl quasi-reference electrodes (QREs) under gamma radiation? How does gamma radiation affect the stability of Ag/AgCl quasi-reference electrodes (QREs)? What is the role of silver/silver chloride (Ag/AgCl) quasi-reference electrodes (QREs) in electrochemical measurements under gamma radiation for corrosion studies? What is the antibacterial activity of Ag/AgCl nanoparticles synthesized with different sugar ligands against multidrug-resistant Escherichia coli? How does the presence of chloride ions affect the interaction between L-Arginine and silver ions during the synthesis of Ag/AgCl nanoparticles? How does the presence of L-Arginine affect the synthesis and properties of Ag/AgCl nanoparticles when using sugar ligands? What are the synthetic routes explored for the preparation of crinamic acid and its derivatives, and what is the significance of these compounds in biological activity? How does calpastatin overexpression affect podocyte autophagy and kidney injury in the context of Angiotensin II-induced hypertension? What is the mechanism by which Angiotensin II inhibits autophagy in podocytes? What is the role of gilvocarcin (GV) in inducing DNA damage and its potential application in photochemotherapy? How does gilvocarcin (GV) compare to 8-methoxypsoralen (8-MOP) in terms of potency and mechanism of action? What are the specific photophysical properties of gilvocarcin (GV) that contribute to its high potency? How does the one-pot HPLC method enable the simultaneous quantification of hydrogen peroxide and organic peroxides? Why is it important to differentiate between hydrogen peroxide and organic peroxides in pharmaceutical and food industries? What is the significance of using hydroxydi-p-tolylborane in the one-pot HPLC method? What are the implications of the hydrogen peroxide and organic peroxide content in pharmaceutical excipients and food samples? What are the effects of hydrogen peroxide on slow- and fast-growing NIH/3T3-derived cultures in relation to cellular senescence and transformation? What is the role of hydrogen peroxide (H₂O₂) in the photodegradation of polyethylene terephthalate (PET) and its monomers bis(2-hydroxyethyl)terephthalate (BHET) and terephthalic acid (TPA)? What is the extent of mineralization achieved in the degradation of TPA and BHET using excimer lamps and hydrogen peroxide?