What is the role of gilvocarcin (GV) in inducing DNA damage and its potential application in photochemotherapy?

Label:chem

Topic
Gilvocarcin (GV) is an antitumor antibiotic isolated from streptomycetes gilvotanareous. It belongs to a group of isocoumarins known for their DNA-damaging activities. GV has a strong tendency to intercalate with DNA and absorbs UVA and visible light efficiently, making it a candidate for photochemotherapy.
Answer
Gilvocarcin (GV) induces single-strand breaks in DNA upon photoactivation with UV radiation, particularly at wavelengths around 398 nm. It is highly potent due to its strong DNA intercalation ability and efficient absorption of UVA radiation. GV can also inhibit lymphocyte response to phytohemagglutinin stimulation, even in the absence of light, suggesting potential applications in photochemotherapy for conditions like psoriasis and cutaneous T-cell lymphoma.
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