How does huperzine-A protect against cadmium chloride-induced cytotoxicity in SH-SY5Y cells?

Label:chem

Topic
Cadmium chloride induces cytotoxicity by increasing oxidative stress and disrupting cellular homeostasis. SH-SY5Y cells are a commonly used model for studying neurotoxicity.
Answer
Huperzine-A protects against cadmium chloride-induced cytotoxicity by reducing lactate dehydrogenase (LDH) release and reactive oxygen species (ROS) production. It also helps maintain the levels of antioxidant enzymes, thereby reducing oxidative damage and enhancing cell survival.
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