What are the potential mechanisms behind the molting defects caused by dexlansoprazole in C. elegans?

Label:chem

Topic
Dexlansoprazole, a proton-pump inhibitor, causes molting defects and pharyngeal blockages in C. elegans when exposure occurs during larval development. Molting is a complex process in C. elegans involving the shedding of the old cuticle and the production of a new one, regulated by various conserved molecular pathways.
Answer
The molting defects caused by dexlansoprazole in C. elegans could be due to its disruption of various processes involved in molting, such as vesicular trafficking, steroid-hormone signaling, developmental timing, and hedgehog-like signaling. The defects observed include incomplete release of the old cuticle and blockage within the pharyngeal lumen. Identifying the molecular targets of dexlansoprazole in C. elegans could provide insights into both the biology of molting and conserved processes that might be similarly disrupted in humans.
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