What is the role of huperzine-A in modulating oxidative stress in cadmium chloride-induced neurotoxicity?

Label:chem

Topic
Oxidative stress is a key factor in neurodegenerative diseases like Huntington's disease (HD), where reactive oxygen species (ROS) and lipid peroxidation lead to neuronal damage. Cadmium chloride is known to induce oxidative stress by increasing ROS levels and reducing antioxidant enzyme activities.
Answer
Huperzine-A significantly reduces oxidative stress in cadmium chloride-induced neurotoxicity by decreasing ROS levels and restoring antioxidant enzyme activities such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). This helps protect neurons from oxidative damage.
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