What is the effect of SGI-1776 on normal peripheral blood mononuclear cells (PBMCs) compared to MCL cells?

Label:chem

Topic
SGI-1776 is designed to target Pim kinases, which are overexpressed in MCL cells but not in normal PBMCs. This selective targeting is important for minimizing toxicity to healthy cells.
Answer
SGI-1776 treatment does not significantly affect normal PBMCs, unlike MCL cells. In normal PBMCs, SGI-1776 does not consistently reduce the phosphorylation of Pim kinase targets or the levels of short-lived proteins like Mcl-1 and cyclin D1. Additionally, apoptosis is not induced in normal PBMCs after SGI-1776 treatment, suggesting that the drug selectively targets MCL cells without affecting healthy cells.
Return to Home Chemical List
Knowledge you may be interested in
How does SGI-1776 affect the phosphorylation status of c-Myc and 4E-BP1 in MCL cells? What is the effect of SGI-1776 on Mcl-1 and cyclin D1 protein levels in MCL cells? How does SGI-1776 affect global RNA synthesis in MCL cell lines? What is the role of SGI-1776 in inhibiting Pim kinases in mantle cell lymphoma (MCL)? How does SGI-1776 affect mitochondrial function in SACC cells? What is the impact of SGI-1776 on apoptosis in SACC cells? How does SGI-1776 influence cell migration and invasion in SACC cells? What is the effect of SGI-1776 on cell proliferation in SACC cells? How does SGI-1776 affect Pim-1 expression and activity in SACC cells? What is the proposed mechanism for the formation of 2-aminophenoxazine-3-one from 2-aminophenol? What is the role of huperzine-A in modulating oxidative stress in cadmium chloride-induced neurotoxicity? How does huperzine-A interact with huntingtin protein in the context of Huntington's disease? What is the effect of huperzine-A on neurotransmitter levels in cadmium chloride-induced neurotoxicity? How does huperzine-A protect against cadmium chloride-induced cytotoxicity in SH-SY5Y cells? What is the role of huperzine-A in modulating Wnt signaling pathways in neurodegenerative diseases? How does huperzine-A affect acetylcholinesterase activity in neurodegenerative conditions? What is the effect of huperzine-A on the neuronal behavior of Drosophila melanogaster in cadmium chloride-induced neurotoxicity? What is the role of hexaphenylbenzene (HPB) in the synthesis of p-extended [12]cycloparaphenylene (CPP) derivatives? How does the use of different reducing agents (low-valent titanium vs. sodium naphthalenide) affect the synthesis of [6]CCHPB and its C2-symmetric congener? What is the role of FeCl3 in the oxidative cyclodehydrogenation of [6]CCHPB and its C2-symmetric congener?