What is the role of huperzine-A in modulating Wnt signaling pathways in neurodegenerative diseases?

Label:chem

Topic
Wnt signaling pathways are involved in synaptic development and plasticity. Dysregulation of these pathways can contribute to neurodegenerative diseases like Huntington's disease.
Answer
Huperzine-A significantly reduces the mRNA levels of Wnt3a and CAMK2A in cadmium chloride-treated SH-SY5Y cells. This suggests that huperzine-A may help normalize Wnt signaling pathways, thereby reducing neurotoxicity and protecting against neurodegenerative effects.
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