How does huperzine-A interact with huntingtin protein in the context of Huntington's disease?

Label:chem

Topic
Mutant huntingtin protein is a hallmark of Huntington's disease, causing disruptions in intracellular pathways and contributing to neurodegeneration.
Answer
Huperzine-A binds to the huntingtin protein with a binding energy of −7.85 kcal/mol, interacting with amino acids LYS2236, TYR2576, and HIS2574. This interaction suggests that huperzine-A may help stabilize the huntingtin protein or modulate its effects, potentially reducing neurodegenerative symptoms.
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