How does SGI-1776 affect the phosphorylation status of c-Myc and 4E-BP1 in MCL cells?

Label:chem

Topic
Pim kinases phosphorylate c-Myc at Ser62, stabilizing it, and 4E-BP1 at Thr37/46, promoting cap-dependent translation. These processes are critical for transcriptional and translational regulation in MCL cells.
Answer
SGI-1776 treatment reduces the phosphorylation of c-Myc at Ser62 and 4E-BP1 at Thr37/46 in MCL cell lines such as JeKo-1 and Mino. In JeKo-1 cells, phospho-c-Myc (Ser62) and phospho-4E-BP1 (Thr37/46) levels decrease in a dose-dependent manner. In Mino cells, phospho-4E-BP1 (Thr37/46) levels also decline, but phospho-c-Myc (Ser62) levels are less affected. This inhibition of phosphorylation disrupts transcriptional and translational processes, contributing to cell death.
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