How do ticlopidine and sertaconazole cause lethality in C. elegans?

Label:chem

Topic
Both ticlopidine and sertaconazole cause distinct morphological changes in the pharynx of C. elegans, leading to lethality. A study explores the potential mechanisms behind these effects, including the role of sphingomyelin in the accumulation of these drugs in the pharyngeal marginal cells.
Answer
Ticlopidine and sertaconazole cause lethality in C. elegans through different mechanisms. Ticlopidine likely requires sphingomyelin generated by SMS-5 in the marginal cells of the pharynx for visible accumulations, but it causes lethality independent of these accumulations. Sertaconazole may require SMS-5 for both accumulations and lethality or cause lethality at lower concentrations in worms lacking SMS-5. A study suggests that the sphingomyelin content of plasma membranes could be a conserved feature that affects the interaction of these drugs with tissues in both C. elegans and humans.
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