How does SGI-1776 affect mitochondrial function in SACC cells?

Label:chem

Topic
Mitochondria play a central role in apoptosis regulation, and mitochondrial depolarization is a key event in the apoptotic process.
Answer
SGI-1776 treatment leads to mitochondrial depolarization in SACC cells, as indicated by a decrease in the mitochondrial membrane potential (MMP). This depolarization is a hallmark of early apoptosis and contributes to the induction of apoptosis in SACC cells.
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