What is the impact of SGI-1776 on apoptosis in SACC cells?

Label:chem

Topic
Apoptosis, or programmed cell death, is a critical process that can be disrupted in cancer cells, leading to uncontrolled growth. Pim-1 is known to influence apoptosis through various pathways.
Answer
SGI-1776 induces apoptosis in SACC cells, as shown by increased early apoptosis rates and elevated caspase-3 activity. This effect is dose-dependent, with higher concentrations of SGI-1776 leading to greater induction of apoptosis.
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