How does SGI-1776 affect Pim-1 expression and activity in SACC cells?

Label:chem

Topic
SGI-1776 is a small molecule inhibitor of the Pim kinase family, designed to target and inhibit Pim-1 activity.
Answer
SGI-1776 down-regulates Pim-1 protein expression and inhibits Pim-1 kinase activity in a dose-dependent manner in SACC cells. This inhibition leads to reduced cell proliferation, decreased invasive ability, and increased apoptosis.
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