What is the effect of SGI-1776 on cell proliferation in SACC cells?

Label:chem

Topic
Cell proliferation is a critical process in cancer progression, and Pim-1 is known to promote cell proliferation in various cancers.
Answer
SGI-1776 treatment significantly reduces cell proliferation in SACC cells, as evidenced by decreased DNA synthesis (measured by BrdU incorporation) and reduced colony formation. The cell cycle is also arrested, with an increase in the percentage of cells in the G0/G1 and G2/M phases and a decrease in the S phase.
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