How does the presence of methanol affect the oxidation reaction of 2-aminophenol mediated by (diacetoxyiodo)benzene?

Label:chem

Topic
A study explores the effect of methanol as an additive and solvent on the oxidation of 2-aminophenol by (diacetoxyiodo)benzene.
Answer
Methanol significantly increases the reaction rate of the oxidation of 2-aminophenol by (diacetoxyiodo)benzene. This effect is attributed to the formation of a methoxy radical, which stabilizes the reactive intermediate and accelerates the process. The presence of methanol results in a nearly 50-fold increase in the reaction rate compared to reactions carried out in pure acetonitrile.
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