What are the potential therapeutic implications of Combretastatin A4 (CA-4) based on its selective cytotoxicity and antioxidant properties?

Label:chem

Topic
Selective cytotoxicity and antioxidant properties are desirable traits for chemotherapeutic agents, as they can enhance the efficacy of cancer treatment while reducing adverse effects on healthy cells.
Answer
CA-4 exhibited selective cytotoxicity towards cancer cells while sparing normal PBMCs and trophoblast cells. Additionally, it demonstrated antioxidant and antigenotoxic properties in normal cells, suggesting that it could be a promising candidate for cancer therapy with reduced toxicity to healthy tissues. Further in vivo studies are warranted to validate its therapeutic potential.
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