What is the impact of Combretastatin A4 (CA-4) on DNA damage in human PBMCs under oxidative stress conditions?

Label:chem

Topic
DNA damage induced by oxidative stress can lead to genomic instability and is a critical factor in the development of various diseases, including cancer. CA-4 has been shown to exacerbate DNA damage in cancer cells, but its effects on normal cells under oxidative stress are not well characterized.
Answer
CA-4 demonstrated antigenotoxic effects in PBMCs by reducing DNA damage induced by hydrogen peroxide (H2O2) at concentrations up to 1 μM. This suggests that CA-4 can protect normal cells from oxidative stress-induced DNA damage, contrasting its pro-damaging effects in cancer cells.
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