How does Combretastatin A4 (CA-4) influence the production of reactive oxygen species (ROS) in PBMCs exposed to oxidative stress?

Label:chem

Topic
ROS are a byproduct of normal cellular metabolism and can cause oxidative damage to cellular components when produced in excess. CA-4 has been reported to increase ROS levels in cancer cells, leading to oxidative stress and cell death.
Answer
In PBMCs exposed to oxidative stress (induced by H2O2), CA-4 significantly reduced ROS levels in a concentration-dependent manner. This indicates that CA-4 can mitigate oxidative stress in healthy lymphocytes, highlighting its potential protective role against oxidative damage in normal cells.
Return to Home Chemical List
Knowledge you may be interested in
What is the impact of Combretastatin A4 (CA-4) on DNA damage in human PBMCs under oxidative stress conditions? How does Combretastatin A4 (CA-4) affect the viability and metabolic activity of human PBMCs compared to cancer cell lines? What is the role of Combretastatin A4 (CA-4) in modulating oxidative stress in human peripheral blood mononuclear cells (PBMCs)? How effective is cidofovir in treating molluscum contagiosum? What are the clinical outcomes of using cidofovir for treating verruca vulgaris and verruca plana? What are the common side effects of cidofovir when used topically and intralesionally? How is cidofovir administered for cutaneous applications? What is the mechanism of action of cidofovir in treating viral infections? What were the key findings from the binding affinity and functional activity assays of the synthesized naltrindole (NTI) derivatives? What is the impact of the S=O moiety in sulfonamide-type naltrindole (NTI) derivatives on their functional activities? What are the potential therapeutic implications of Combretastatin A4 (CA-4) based on its selective cytotoxicity and antioxidant properties? What are the environmental risks associated with fipronil (FIP) and imidacloprid (IMID) used in pet ectoparasiticides? How do FIP and IMID affect marine organisms? What are the potential toxic effects of fipronil (FIP) and imidacloprid (IMID) on human cells? What is the impact of pentosidine on adipose tissue metabolism? How does pentosidine affect body weight and adipose tissue histopathology in rats? What are the key metabolic pathways disrupted by pentosidine in adipose tissue? How does pentosidine affect the levels of specific metabolites in adipose tissue? What is the significance of the changes in pyruvic acid and α-ketoglutaric acid levels in adipose tissue exposed to pentosidine? How does acetylation affect the cytotoxic and antioxidant properties of natural triterpenes?