What is the role of Combretastatin A4 (CA-4) in modulating oxidative stress in human peripheral blood mononuclear cells (PBMCs)?

Label:chem

Topic
Oxidative stress is characterized by an imbalance between the production of reactive oxygen species (ROS) and the ability of cells to detoxify these reactive intermediates, leading to cellular damage. CA-4 is a plant-derived compound known for its antitumor properties, but its effects on oxidative stress in non-cancerous cells, such as PBMCs, are less clear.
Answer
CA-4 exerts an antioxidant effect in PBMCs by reducing ROS levels under oxidative stress conditions. This effect was observed at concentrations ranging from 1 to 200 μM, indicating that CA-4 can protect healthy lymphocytes from oxidative damage.
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