What are the key metabolic pathways disrupted by pentosidine in adipose tissue?

A study used untargeted metabolomics to identify differential metabolites and disrupted metabolic pathways in adipose tissue of rats exposed to pentosidine.

The key metabolic pathways disrupted by pentosidine include ascorbate and aldarate metabolism, glycine, serine, and threonine metabolism, sulfur metabolism, pyruvate metabolism, aminoacyl-tRNA biosynthesis, alanine, aspartate, and glutamate metabolism, glyoxylate and dicarboxylate metabolism, the TCA cycle, glycolysis/gluconeogenesis, inositol phosphate metabolism, cysteine and methionine metabolism, and pentose and glucuronate interconversions. These pathways are crucial for energy metabolism, fatty acid metabolism, and amino acid metabolism, indicating that pentosidine exposure can lead to significant metabolic disturbances in adipose tissue.