How is cidofovir administered for cutaneous applications?

Various administration routes for cidofovir, including topical, intralesional, and intravenous methods.

Cidofovir can be administered in several ways for cutaneous applications:
Topical: Commonly compounded as a 0.5% to 3% formulation in cream, ointment, or gel. It is applied daily or twice daily for at least 1 week up to 52 weeks.
Intralesional (IL): Diluted to concentrations ranging from 2.5 mg/mL to 37.5 mg/mL (most commonly 15 mg/mL) and injected directly into the lesion using serial puncture or crosshatching techniques.
Intravenous (IV): Used in cases of extensive disease or critical illness, with dosages ranging from 3.5 to 5 mg/kg, often administered with probenecid to reduce nephrotoxicity.