How does pentosidine affect body weight and adipose tissue histopathology in rats?

Label:chem

Topic
A study aimed to investigate the acute toxicity of pentosidine on adipose tissue in rats by analyzing body weight changes and histopathological alterations.
Answer
Pentosidine exposure significantly inhibited body weight gain in rats in a dose-dependent manner. Histopathological analysis revealed that adipocytes in the high-dose group exhibited remarkable changes in size and shape, with some cells significantly larger than those in the normal diet group. Additionally, cell membranes appeared damaged, and inflammatory cell infiltration was observed. These results indicate that pentosidine exhibits toxicity in adipose tissue, leading to histological alterations and weight changes.
Return to Home Chemical List
Knowledge you may be interested in
What is the impact of pentosidine on adipose tissue metabolism? What are the potential toxic effects of fipronil (FIP) and imidacloprid (IMID) on human cells? How do FIP and IMID affect marine organisms? What are the environmental risks associated with fipronil (FIP) and imidacloprid (IMID) used in pet ectoparasiticides? What are the potential therapeutic implications of Combretastatin A4 (CA-4) based on its selective cytotoxicity and antioxidant properties? How does Combretastatin A4 (CA-4) influence the production of reactive oxygen species (ROS) in PBMCs exposed to oxidative stress? What is the impact of Combretastatin A4 (CA-4) on DNA damage in human PBMCs under oxidative stress conditions? How does Combretastatin A4 (CA-4) affect the viability and metabolic activity of human PBMCs compared to cancer cell lines? What is the role of Combretastatin A4 (CA-4) in modulating oxidative stress in human peripheral blood mononuclear cells (PBMCs)? How effective is cidofovir in treating molluscum contagiosum? What are the key metabolic pathways disrupted by pentosidine in adipose tissue? How does pentosidine affect the levels of specific metabolites in adipose tissue? What is the significance of the changes in pyruvic acid and α-ketoglutaric acid levels in adipose tissue exposed to pentosidine? How does acetylation affect the cytotoxic and antioxidant properties of natural triterpenes? What are the results of the molecular docking analysis of triterpenes with the p53Y220 protein? How do the ADMETox properties of acetylated triterpenes compare to their non-acetylated counterparts? What are the implications of the cytotoxic activity of acetylated triterpenes on cancer cell lines? How does short-term exposure to chloramine-T solution affect the bonding performance of chemical-cured adhesives? What are the effects of chloramine-T on the mechanical properties of dental adhesives? What insights did the study provide regarding the nanoleakage in chemical-cured adhesives exposed to chloramine-T?