What is the role of Zileuton in modulating immune responses during coronavirus infection?

Label:chem

Topic
Severe COVID-19 is characterized by exacerbated inflammatory responses, which can lead to severe acute respiratory syndrome (SARS), respiratory failure, and multiple organ failure. Zileuton (Zi) is a selective inhibitor of 5-lipoxygenase (5-LO), an enzyme involved in the production of inflammatory lipid mediators such as leukotrienes (LTs) and lipoxins (LXs). A study investigates the effects of Zi on immune responses and lung function in models of severe coronavirus infection.
Answer
Zileuton modulates host immune responses by reducing pro-inflammatory cytokines and increasing anti-inflammatory cytokines like IL-10, thereby improving lung function and survival rates without affecting the host's ability to clear the virus.
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