How does Zileuton influence the adaptive immune response in the spleen during MHV-3 infection?

Label:chem

Topic
The adaptive immune response, involving CD4+ and CD8+ T cells, is crucial for viral containment and resolution of infection. A study evaluated the effects of Zileuton on the adaptive immune response in the spleen of infected mice.
Answer
At 5 days post-infection, Zileuton treatment increased the number of CD8+ T cells in the spleen. The treatment also promoted a shift towards a more anti-inflammatory profile, with increased numbers of IL-10-producing and FOXP3+ T regulatory cells (Tregs) among both CD4+ and CD8+ T cells. This suggests that Zileuton helps regulate the immune response to prevent excessive inflammation.
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