What are the effects of Zileuton on cytokine levels and immune cell profiles in the lungs of MHV-3-infected mice?

Label:chem

Topic
Inflammatory cytokines and immune cell infiltration play a critical role in the pathogenesis of severe coronavirus infections. A study evaluated the impact of Zileuton on cytokine levels and immune cell profiles in the lungs of infected mice.
Answer
Zileuton treatment led to higher levels of IL-10 and IFN-γ, while reducing levels of pro-inflammatory cytokines like CXCL-2, IL-1β, and CXCL-1. The treatment also increased the number of IL-10-producing neutrophils and reduced TNF-producing dendritic cells in the lungs. At 5 days post-infection, treated mice showed increased numbers of Th2, Treg CD4+, and Treg CD8+ cells producing IL-10, and reduced Th1 infiltrating cells.
Return to Home Chemical List
Knowledge you may be interested in
How does Zileuton affect survival and clinical outcomes in a mouse model of severe acute respiratory syndrome (SARS) caused by mouse hepatitis virus (MHV-3)? What is the role of Zileuton in modulating immune responses during coronavirus infection? What are the key components used to formulate granisetron-loaded cubosomes (GS-CBS)? How does the intranasal delivery of granisetron via nanostructured cubosomes improve the management of chemotherapy-induced emesis? How does lanreotide treatment affect T cell signaling pathways in vivo? Which specific genes were differentially expressed in responders versus non-responders before lanreotide treatment? What are the in vivo effects of lanreotide on T cell gene expression in NET patients? How does lanreotide affect T cell function and survival in vitro? What is the role of lanreotide in the treatment of gastroenteropancreatic neuroendocrine tumors (NETs)? What are the potential clinical implications of using Olprinone (OLP) for hepatoprotection? How does Zileuton impact cardiopulmonary function in MHV-3-infected mice? How does Zileuton influence the adaptive immune response in the spleen during MHV-3 infection? What is the significance of the N-substituent in the functional activities of naltrindole (NTI) derivatives for the δ opioid receptor (DOR)? How do the binding affinities and functional activities of the synthesized naltrindole (NTI) derivatives compare among different substituents? What is the impact of the S=O moiety in sulfonamide-type naltrindole (NTI) derivatives on their functional activities? What were the key findings from the binding affinity and functional activity assays of the synthesized naltrindole (NTI) derivatives? What is the mechanism of action of cidofovir in treating viral infections? How is cidofovir administered for cutaneous applications? What are the common side effects of cidofovir when used topically and intralesionally? What are the clinical outcomes of using cidofovir for treating verruca vulgaris and verruca plana?