How does Zileuton affect survival and clinical outcomes in a mouse model of severe acute respiratory syndrome (SARS) caused by mouse hepatitis virus (MHV-3)?

Label:chem

Topic
MHV-3 infection in mice is used as a model for severe COVID-19, as it induces severe lung pathology and systemic disease. A study evaluated the effects of Zileuton treatment on clinical parameters, survival rates, and lung function in this model.
Answer
Zileuton treatment significantly improved survival rates, delayed mortality, reduced weight loss, and improved clinical scores in MHV-3-infected mice. The treatment also maintained lung function and reduced inflammatory scores in the lungs, independent of viral load control.
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