How does Zileuton impact cardiopulmonary function in MHV-3-infected mice?

Label:chem

Topic
Severe COVID-19 often leads to cardiopulmonary complications, including reduced lung compliance and cardiac alterations. A study assessed the effects of Zileuton on cardiopulmonary function in a mouse model of severe coronavirus infection.
Answer
Zileuton treatment maintained lung compliance closer to that of control mice, as measured by pressure-volume (PV) curves. Additionally, treated mice exhibited milder cardiac alterations compared to untreated infected mice, as shown by electrocardiogram (ECG) analysis.
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