What histopathological changes are observed in the liver after treatment with Olprinone (OLP)?

Label:chem

Topic
Histopathological analysis provides insights into the extent of liver damage and the effectiveness of hepatoprotective agents.
Answer
Histological examination of rat livers treated with Olprinone (OLP) showed a significant reduction in pathological liver damage, including inflammatory cell infiltration, hemorrhagic manifestations, and single-cell and focal necrosis. OLP also decreased neutrophil infiltration, as evidenced by reduced myeloperoxidase (MPO)-positive cells. However, no significant differences in hepatocyte apoptosis were observed between the treated and untreated groups.
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