How does the intranasal delivery of granisetron via nanostructured cubosomes improve the management of chemotherapy-induced emesis?

Label:chem

Topic
Chemotherapy-induced emesis is a common side effect of cytotoxic chemotherapy, significantly affecting patients' quality of life. Traditional antiemetic drugs like granisetron have limitations in terms of bioavailability and delivery methods.
Answer
The intranasal delivery of granisetron via nanostructured cubosomes enhances the management of chemotherapy-induced emesis by improving drug delivery to the brain through the nose-to-brain pathway. This method bypasses the blood-brain barrier, increases bioavailability, and provides a non-invasive and rapid onset of action compared to traditional oral or injectable forms.
Return to Home Chemical List
Knowledge you may be interested in
How does lanreotide treatment affect T cell signaling pathways in vivo? Which specific genes were differentially expressed in responders versus non-responders before lanreotide treatment? What are the in vivo effects of lanreotide on T cell gene expression in NET patients? How does lanreotide affect T cell function and survival in vitro? What is the role of lanreotide in the treatment of gastroenteropancreatic neuroendocrine tumors (NETs)? What are the potential clinical implications of using Olprinone (OLP) for hepatoprotection? How does Olprinone (OLP) affect NF-κB activation in hepatocytes? What histopathological changes are observed in the liver after treatment with Olprinone (OLP)? How does Olprinone (OLP) influence inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in the liver? What is the effect of Olprinone (OLP) on pro-inflammatory cytokines and chemokines in the liver? What are the key components used to formulate granisetron-loaded cubosomes (GS-CBS)? What is the role of Zileuton in modulating immune responses during coronavirus infection? How does Zileuton affect survival and clinical outcomes in a mouse model of severe acute respiratory syndrome (SARS) caused by mouse hepatitis virus (MHV-3)? What are the effects of Zileuton on cytokine levels and immune cell profiles in the lungs of MHV-3-infected mice? How does Zileuton impact cardiopulmonary function in MHV-3-infected mice? How does Zileuton influence the adaptive immune response in the spleen during MHV-3 infection? What is the significance of the N-substituent in the functional activities of naltrindole (NTI) derivatives for the δ opioid receptor (DOR)? How do the binding affinities and functional activities of the synthesized naltrindole (NTI) derivatives compare among different substituents? What is the impact of the S=O moiety in sulfonamide-type naltrindole (NTI) derivatives on their functional activities? What were the key findings from the binding affinity and functional activity assays of the synthesized naltrindole (NTI) derivatives?