What are the pharmacokinetic challenges of resveratrol, and how do they affect its clinical use?

Label:chem

Topic
Despite its therapeutic potential, resveratrol's clinical application is limited by poor bioavailability.
Answer
Resveratrol exhibits low oral bioavailability due to extensive first-pass metabolism by cytochrome P450s, UDP-glucuronosyltransferases, and sulfotransferases, resulting in plasma concentrations (0.3–2.4 μM) far below in vitro effective levels (>10 μM).
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