How does resveratrol influence amyloid-beta (Aβ) accumulation in Alzheimer's disease?

Label:chem

Topic
Aβ plaques are a hallmark of Alzheimer's pathology, disrupting neuronal communication and triggering inflammation.
Answer
Resveratrol reduces Aβ accumulation by directly binding to monomeric and fibrillar forms of Aβ (1–40 and 1–42), promoting proteasome-dependent degradation of Aβ, and enhancing autophagy via the TyrRS-PARP1-SIRT1 signaling pathway.
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