What mechanisms does resveratrol use to reduce Tau protein hyperphosphorylation?

Label:chem

Topic
Hyperphosphorylated Tau forms neurofibrillary tangles, a key feature of Alzheimer's disease.
Answer
Resveratrol reduces Tau hyperphosphorylation by activating protein phosphatase 2A (PP2A) via disruption of the MID1-PP2A complex, inhibiting GSK-3β and CaMKII, and activating the PI3K/Akt pathway.
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