What explains the lack of efficacy of vitamin K supplementation in CKD?

Label:chem

Topic
Chronic kidney disease (CKD) patients often have functional vitamin K deficiency due to dietary restrictions, medications, and impaired metabolism.
Answer
Impaired absorption: Phosphate binders (used in CKD) reduce vitamin K absorption.
Altered pharmacokinetics: Uremia in CKD reduces MK-7 uptake and disrupts vitamin K recycling.
Insufficient dosing: Standard doses may not overcome these metabolic barriers.
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