Which compounds in vine tea contain the pyrogallol moiety and are potentially responsible for anti-SARS-CoV-2 activity?

Label:chem

Topic
Flavonoids in vine tea were reported to inhibit SARS-CoV-2 via covalent binding to the 3CLpro enzyme, supposedly through their pyrogallol (catechol) moieties.
Answer
At least nine bioactive phenolics contain the pyrogallol moiety: ampelopsin (6), myricetin (19), myricetin 3-O-galactoside (15), myricitrin (16), epigallocatechin (5), epigallocatechin gallate (8), gallocatechin gallate (10), epicatechin gallate (12), and catechin gallate (14). These compounds may contribute to the anti-SARS-CoV-2 activity in addition to the main compound ampelopsin.
Return to Home Chemical List
Knowledge you may be interested in
How many bioactive compounds were systematically identified in vine tea, and how were they classified? What is the characteristic compound of Ampelopsis grossedentata (vine tea)? What is the antifungal mechanism of action for the synthesized phenolic acid triazole derivatives, and how do they compare to carbendazim? What are the major fatty acids found in Scenedesmus obliquus BGP and Porphyridium cruentum oils? How does the solvent influence the structure and luminescence of Pb(II) benzoate complexes? Which hydrogen-bonding interactions dominate solute transfer into isobutyl acetate? What is the Abraham general solvation model and how is it applied to isobutyl acetate? How was the successful conjugation of pea protein hydrolysates (PPH) and D-xylose confirmed, and what structural changes were observed? How were the pea protein hydrolysates (PPH) prepared, and what are the optimal conditions for glycosylation with D-xylose? What is the impact of solvent polarity and viscosity on the dynamic equilibrium of ligands in colloidal metal chalcogenide QDs? What is the nucleation mechanism of p-methoxybenzoic acid (PMBA) in an ethanol-water system at different saturation temperatures? How does the ethanol mass fraction affect the metastable zone width (MSZW) and interfacial energy of p-methoxybenzoic acid (PMBA)? How does p-methoxybenzoic acid (PMBA) solubility vary with temperature and ethanol mass fraction? What are the primary forms of vitamin K, and where are they found? How is vitamin K status measured, and why are indirect markers preferred? Does vitamin K supplementation improve kidney function in CKD patients? What explains the lack of efficacy of vitamin K supplementation in CKD? What is the chemical structure of resveratrol (RSV), and what is its molecular weight? How does resveratrol influence amyloid-beta (Aβ) accumulation in Alzheimer's disease? What mechanisms does resveratrol use to reduce Tau protein hyperphosphorylation?