What is the antifungal mechanism of action for the synthesized phenolic acid triazole derivatives, and how do they compare to carbendazim?

Label:chem

Topic
A study discusses the synthesis and antifungal activity of novel phenolic acid triazole derivatives, comparing their efficacy to the commercial fungicide carbendazim.
Answer
The synthesized derivatives exhibited antifungal activity by inhibiting the growth of seven plant pathogenic fungi. Specifically, compound 1a (methyl 4-(2-bromoethoxy)benzoate) showed the highest inhibitory rate against Rhizoctonia solani AG1 (88.6% at 200 μg/mL). Compound 2a (methyl 4-(2-(1H-1,2,4-triazol-1-yl)ethoxy)benzoate) demonstrated superior activity against Fusarium moniliforme (76.1%) and Sphaeropsis sapinea (75.4%) at 200 μg/mL, outperforming carbendazim (which had 65.0% and 63.5% inhibition rates, respectively). The mechanism is attributed to the synergistic effect of the phenolic acid and triazole moieties, though the exact molecular target was not specified.
Return to Home Chemical List
Knowledge you may be interested in
What are the major fatty acids found in Scenedesmus obliquus BGP and Porphyridium cruentum oils? How does the solvent influence the structure and luminescence of Pb(II) benzoate complexes? Which hydrogen-bonding interactions dominate solute transfer into isobutyl acetate? What is the Abraham general solvation model and how is it applied to isobutyl acetate? How was the successful conjugation of pea protein hydrolysates (PPH) and D-xylose confirmed, and what structural changes were observed? How were the pea protein hydrolysates (PPH) prepared, and what are the optimal conditions for glycosylation with D-xylose? What is the impact of solvent polarity and viscosity on the dynamic equilibrium of ligands in colloidal metal chalcogenide QDs? How does fenpropidin exert its fungicidal effects and what are its key systemic properties? What is the origin and mechanism of action of zhongshengmycin? What is the primary therapeutic use of rimegepant? What is the characteristic compound of Ampelopsis grossedentata (vine tea)? How many bioactive compounds were systematically identified in vine tea, and how were they classified? Which compounds in vine tea contain the pyrogallol moiety and are potentially responsible for anti-SARS-CoV-2 activity? What is the nucleation mechanism of p-methoxybenzoic acid (PMBA) in an ethanol-water system at different saturation temperatures? How does the ethanol mass fraction affect the metastable zone width (MSZW) and interfacial energy of p-methoxybenzoic acid (PMBA)? How does p-methoxybenzoic acid (PMBA) solubility vary with temperature and ethanol mass fraction? What are the primary forms of vitamin K, and where are they found? How is vitamin K status measured, and why are indirect markers preferred? Does vitamin K supplementation improve kidney function in CKD patients? What explains the lack of efficacy of vitamin K supplementation in CKD?