What are the physiological activities of pyrrole-2-carboxaldehydes (Py-2-C) derived from plants?

Py-2-C derivatives have been isolated from various plant sources, including fruits, leaves, and roots. These compounds have been tested for their biological activities, such as antioxidant effects, cytotoxicity, and enzyme inhibition.

From: "Pyrrole-2-carboxaldehydes: Origins and Physiological Activities", Molecules 2023, 28(6), 2599;

Py-2-C derivatives from plants exhibit diverse physiological activities. For instance, magnolamide from Magnolia coco showed significant inhibitory activity against Cu+-induced LDL oxidation, comparable to known antioxidants like probucol and resveratrol. Pyrrolezanthine-6-methyl ether from Ilex paraguariensis did not show significant HNE inhibitory activity. Compounds from Lycium chinense fruits demonstrated high hepatoprotective activity. These results indicate that Py-2-C derivatives from plants have potential applications in preventing oxidative stress-related diseases and promoting liver health.