How does NPO-2270 affect calpain activity in heart failure models?

Label:chem

Topic
Calpain activity is dysregulated in heart failure, contributing to cardiomyocyte cell death and remodeling. NPO-2270 is designed to inhibit calpain activity.
Answer
NPO-2270 significantly reduces calpain activity in heart failure models, as evidenced by decreased cleavage of calpain substrates such as a-fodrin. This inhibition correlates with reduced myocardial infarction and improved cardiac function, highlighting its therapeutic potential.
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