What is the effect of inclusion complex formation with β-cyclodextrin derivatives on the photostability of the drug candidate 2-(2-nitrovinyl)furan (G-0)?

Label:chem

Topic
2-(2-nitrovinyl)furan (G-0) is a drug candidate with broad-spectrum antimicrobial activity, including antibacterial, antifungal, and antiprotozoal effects. However, its chemical instability and sublimation capacity pose challenges for formulation development. Cyclodextrins are known for their ability to enhance the stability of drugs through the formation of inclusion complexes.

From: "Photodegradation of the antibacterial, antifungal and antiprotozoal drug candidate 2-(2-nitrovinyl) furan (G-0) in solid inclusion complexes with β-cyclodextrin derivatives: Characterization by NMR Spectroscopy and In Silico Toxicity Screening", European Journal of Pharmaceutical Sciences
Answer
The study found that the formation of inclusion complexes with hydroxypropyl-β-cyclodextrin (HP-β-CD) or sulfobutylether-β-cyclodextrin (SBE-β-CD) did not fully prevent the photodegradation of G-0, but it altered the photodegradation pathways. The main photodegradation product identified was (2Z,4Z)-5-nitropenta-2,4-dienoic acid (NPDA) and its corresponding salt. The inclusion complexes exhibited different degradation profiles compared to physical mixtures, suggesting that cyclodextrins can influence the photostability of G-0.
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