What is the mechanism of action of NPO-2270 in reducing heart failure progression?

Label:chem

Topic
Calpains are overexpressed and overactivated in hearts of patients with heart failure, contributing to cardiomyocyte cell death and remodeling. NPO-2270 is a potent inhibitor of calpains and related cathepsins.
Answer
NPO-2270 reduces heart failure progression by inhibiting calpain activity, which prevents the proteolysis of proteins such as junctophilin-2. This preservation of protein integrity helps maintain the structural and functional integrity of cardiac cells, thereby reducing adverse remodeling and improving cardiac function.
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