What is the role of NPO-2270 in the treatment of heart failure (HF)?

Label:chem

Topic
NPO-2270 is a potent and selective cysteine protease inhibitor that has been shown to limit myocardial infarction and prevent adverse remodeling progression in murine models of heart failure. It is designed to inhibit calpains, a family of non-lysosomal cysteine proteases that contribute to heart failure through the proteolysis of various proteins.
Answer
NPO-2270 is used to limit myocardial infarction and prevent adverse remodeling progression in heart failure models. It is more effective than enalapril, a conventional heart failure treatment, in improving cardiac function and reducing calpain activity. Its effects correlate with reduced calpain cleavage of junctophilin-2, preserving T-tubule morphology and improving cardiac function.
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