How does the silane-modified polyampholyte (S-PA) hydrogel coating resist protein adsorption?

Label:chem

Topic
Protein adsorption is a critical factor in marine biofouling, as it leads to the formation of conditioning films (CFs) that facilitate microbial adhesion. The S-PA hydrogel coating is designed to resist protein adsorption by maintaining an electrically neutral surface.
Answer
The S-PA hydrogel coating resists protein adsorption due to its electrically neutral surface. This neutrality minimizes the electrostatic interactions between the hydrogel surface and proteins, preventing the formation of conditioning films. The protein adsorption capacity of bovine serum albumin (BSA) on S-PA hydrogel was found to be as low as 5 mg g−1, indicating excellent resistance to protein adsorption.
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