What are the major metabolites formed from pectenotoxin-2 (PTX-2) during in vitro metabolism by rat hepatocytes?

Label:chem

Topic
PTX-2 is rapidly metabolized in rat hepatocytes, forming several oxidized metabolites. Understanding these metabolites is crucial for elucidating the detoxification pathways of PTX-2.
Answer
The major metabolites formed from PTX-2 include a monohydroxylated metabolite (M1) with [M + NH4]+ at m/z 892 and [M + Na]+ at m/z 897, a minor monohydroxylated metabolite (M2) with similar ions, and a dihydroxylated metabolite (M3) with [M + NH4]+ at m/z 908 and [M + Na]+ at m/z 913.
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