What is the role of L-pyroglutamic acid (PG) in the development of the Febuxostat/L-pyroglutamic acid cocrystal (FBX-PG)?

Label:chem

Topic
Febuxostat (FBX) is a poorly water-soluble drug used to treat hyperuricemia and gout. To improve its solubility, cocrystals have been developed. One such cocrystal is FBX-PG, which incorporates L-pyroglutamic acid (PG) as a co-former.
Answer
L-pyroglutamic acid (PG) is used in the FBX-PG cocrystal to enhance the solubility of Febuxostat. The cocrystal formation with PG increases the solubility of FBX by 4-fold, improving its stability and bioavailability in the gastrointestinal tract.
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