What is the role of rhodium-catalysed vinyl 1,4-addition in the synthesis of the CDE ring fragment of pectenotoxin-4?

Label:chem

Topic
The synthesis of the CDE ring fragment of pectenotoxin-4 involves several key steps, including the formation of a complex bicyclic ketal unit. One of the major challenges is to join the ABC and E ring fragments under mild conditions without using a large excess of either component.
Answer
The rhodium-catalysed vinyl 1,4-addition serves as the key C–C bond forming step, allowing the joining of the ABC and E ring fragments under relatively mild conditions. This reaction is crucial for constructing the desired [5,6]-bicyclic ketal structure of the D ring in pectenotoxin-4.
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